Attie Lab Diabetes Database

Genetic architecture | QTL scans | Correlation search tool | SNP search tool | eQTL viewer

QTL scans of expression and clinical traits

Performs QTL scans for gene expression in each of 6 tissues, or >100 diabetes-related clinical traits. Generates graphical plots genome-wide or for specific chromosomes. Sex-specific scans and allele-dependence plots are available. For multiple traits, heat maps can be used for easy visualization.

Chromosomes

Data Source:	LOD Allele dependence (one trait at a time).
Sex:	Both Male Female
Clinical Traits: (Can only be selected with LOD data)
	(Hold Ctrl or Shift key to select multiple traits)
Genes:	Gene Symbol a gene id a substance id Accession Code Entrez ID
Paste list here: (one per row)

Tissues:	Islet Liver Hypothalamus Adipose Gastroc Kidney
Plot Type:	heat map ( Show genomic position of genes ) One or more genes can be entered for performing QTL mapping in any of the 6 tissues listed. One or more clinical traits can also be used for QTL mapping; click on desired traits. Heat maps are best to illustrate results when many performing QTL scans on many traits simultaneously. The allele dependence can be shown for single traits. One can show mapping results genome-wide, or for single chromosomes by selecting a subset.
	Profile scan
Rescale LOD?	Support Peaks None
Clustering?	Yes No
Color Scheme:	Red-blue gray cm heat terrain top
Threshold:	Enter 0 - 1.0
Unit:	cM Mb
Y-Label:	Symbol a_gene_id symbol.a_gene_id none
Image Size:	Width: (inches) - Height: (inches), Font Size: , Resolution:
Plot Title:	Leave blank to use default title.

	I just want to download extracted data. DOT NOT perform analysis now.

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Apo A1 (Apolipoprotein A1) (ug/mL)
BODY LENGTH (cm) 10 wk
BODY LENGTH (cm) 4 wk
BODY LENGTH (cm) 6 wk
BODY LENGTH (cm) 8 wk
Beta-2 Microglobulin (ug/mL)
Brain weight(mg)
CD40 (pg/mL)
CD40 Ligand (pg/mL)
CRP (C Reactive Protein) (ug/mL)
Calbindin (ng/mL)
Clusterin (ug/mL)
Cystatin-C (ng/mL)
EGF (Epidermal Growth Factor) (pg/mL)
Endothelin-1 (pg/mL)
Eotaxin (pg/mL)
FGF-9 (Fibroblast Growth Factor-9) (ng/mL)
FGF-basic (Fibroblast Growth Factor-basic) (ng/mL)
Factor VII (ng/mL)
Fibrinogen (ug/mL)
Fibrinogen (ug/mL) no clotted
GCP-2 (Granulocyte Chemotactic Protein-2) (ng/mL)
GLUCOSE (mg/dl) 10 wk
GLUCOSE (mg/dl) 4 wk
GLUCOSE (mg/dl) 6 wk
GLUCOSE (mg/dl) 8 wk
GM-CSF (Granulocyte Macrophage-Colony Stimulating Factor) (pg/mL)
GST-Mu (ng/mL)
GST-alpha (Glutathione S-Transferase alpha) (ng/mL)
Gastroc. Weight(mg)
Growth Hormone (ng/mL)
HDL mg/dL
HOMA (insulin*glucose/22.5) 10 wk
HOMA (insulin*glucose/22.5) 4 wk
HOMA (insulin*glucose/22.5) 6 wk
HOMA (insulin*glucose/22.5) 8 wk
Haptoglobin (ug/mL)
Heart weight(mg)
Hypothalamus weight(mg)
IFN-gamma (Interferon-gamma) (pg/mL)
IL-10 (Interleukin-10) (pg/mL)
IL-11 (Interleukin-11) (pg/mL)
IL-12p70 (Interleukin-12p70) (ng/mL)
IL-17 (Interleukin-17) (ng/mL)
IL-18 (Interleukin-18) (ng/mL)
IL-1alpha (Interleukin-1alpha) (pg/mL)
IL-1beta (Interleukin-1beta) (ng/mL)
IL-2 (Interleukin-2) (pg/mL)
IL-3 (Interleukin-3) (pg/mL)
IL-4 (Interleukin-4) (pg/mL)
IL-5 (Interleukin-5) (ng/mL)
IL-6 (Interleukin-6) (pg/mL)
IL-7 (Interleukin-7) (ng/mL)
INSULIN (ng/ml) 10 wk
INSULIN (ng/ml) 4 wk
INSULIN (ng/ml) 6 wk
INSULIN (ng/ml) 8 wk
IP-10 (Inducible Protein-10) (pg/mL)
IgA (Immunoglobulin A) (ug/mL)
Insulin (uIU/mL)
KC/GROalpha (Melanoma Growth Stimulatory Activity Protein) (ng/mL)
LDL mg/dL
LIF (Leukemia Inhibitory Factor) (pg/mL)
Leptin (ng/mL)
Liver weight(mg)
Lt. Adipose + Right (Total Fat Weight in grams)
Lymphotactin (pg/mL)
M-CSF (Macrophage-Colony Stimulating Factor) (ng/mL)
MCP-1 (Monocyte Chemoattractant Protein-1) (pg/mL)
MCP-3 (Monocyte Chemoattractant Protein-3) (pg/mL)
MCP-5 (Monocyte Chemoattractant Protein-5) (pg/mL)
MDC (Macrophage-Derived Chemokine) (pg/mL)
MIP-1alpha (Macrophage Inflammatory Protein-1alpha) (ng/mL)
MIP-1beta (Macrophage Inflammatory Protein-1beta) (pg/mL)
MIP-1gamma (Macrophage Inflammatory Protein-1gamma) (ng/mL)
MIP-2 (Macrophage Inflammatory Protein-2) (pg/mL)
MIP-3beta (Macrophage Inflammatory Protein-3beta) (ng/mL)
MMP-9 (Matrix Metalloproteinase-9) (ng/mL)
MPO (Myeloperoxidase) (ng/mL)
Myoglobin (ng/mL)
NEFA mEq/L
NGAL (Lipocalin-2) (ng/mL)
OSM (Oncostatin M) (ng/mL)
Osteopontin (ng/mL)
Plasma_Chloride_mmol
Plasma_Creatinine_umol
Plasma_Potassium_mmol
Plasma_Sodium_mmol
Plasma_Urea_mmol
RANTES (Regulation Upon Activation; Normal T-Cell Expressed and Secreted) (pg/mL)
Rt. Kidney weight(mg)
SAP (Serum Amyloid P) (ug/mL)
SCF (Stem Cell Factor) (pg/mL)
SGOT (Serum Glutamic-Oxaloacetic Transaminase) (ug/mL)
SVL Length (cm)
Sacrifice Weight
Soleus Weight(mg)
Spleen weight(mg)
TIMP-1 (Tissue Inhibitor of Metalloproteinase Type-1) (ng/mL)
TNF-alpha (Tumor Necrosis Factor-alpha) (ng/mL)
TPO (Thrombopoietin) (ng/mL)
TRIGLYCERIDE (mg/dl) 10 wk
TRIGLYCERIDE (mg/dl) 4 wk
TRIGLYCERIDE (mg/dl) 6 wk
TRIGLYCERIDE (mg/dl) 8 wk
Tissue Factor (ng/mL)
Total CHOL. mg/dL
Total Liver Weight(g)
Urinary_Calcium_mmol/L
Urinary_Creatinine_umol/L
Urinary_Magnesium_mmol/L
Urinary_Potassium_mmol/L
Urinary_Protein_g/L
Urinary_Sodium_mmol/L
VCAM-1 (Vascular Cell Adhesion Molecule-1) (ng/mL)
VEGF (Vascular Endothelial Cell Growth Factor) (pg/mL)
WEIGHT (g) 10 wk
WEIGHT (g) 4 wk
WEIGHT (g) 6 wk
WEIGHT (g) 8 wk
adipose.turnover
c-peptide 10 wk
glucose triplicate repeat 10 wk
insulin 10 wk
islet.turnover
liver TG
number islets harvested
pepins (c-peptide/insulin) 10 wk
vWF (von Willebrand Factor) (ng/mL)34:glucose triplicate repeat 10 wk